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Zaborowska-Mazurkiewicz, Michalina; Bizoń, Teresa; Matyszewska, Dorota; Fontaine, Philippe; Bilewicz, Renata, 2024, "Research data for article: Oxidation of lipid membrane cholesterol by cholesterol oxidase and its effects on raft model membrane structure", https://doi.org/10.58132/MDQQDC, Dane Badawcze UW, V1
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In this study, we investigate the effect of cholesterol oxidase on the model of lipid raft membrane model composed of DOPC:Chol:SM (1:1:1). The planar monolayers and liposomes were employed to follow membrane cholesterol oxidation to cholestenone catalyzed by ChOx and changes in the lipid membrane structure accompanying this reaction. Changes in the structure of liposomes in the presence of the enzyme were reflected in the changes in hydrodynamic diameter and fluorescence microscopy images. In contrast, changes in surface properties of planar membranes were evaluated by grazing incidence X-ray diffraction (GIXD) and Brewster angle microscopy. UV-Vis absorbance measurements confirmed the activity of the enzyme in the tested systems. A better understanding of the interactions between the enzyme and the cell membrane may help find alternative ways to decrease excessive cholesterol levels.
model biological membranes, cholesterol oxidation, Langmuir technique, liposomes
M. Zaborowska, T. Biozń, D. Matyszewska, P. Fontaine, R. Bilewicz, Oxidation of lipid membrane cholesterol by cholesterol oxidase and its effects on raft model membrane structure, Colloids and Surfaces B: Biointerfaces 2025, 245, 114191. https://doi.org/10.1016/j.colsurfb.2024.114191 https://doi.org/10.1016/j.colsurfb.2024.114191 doi: 10.1016/j.colsurfb.2024.114191
CC BY - Creative Commons Attribution 4.0
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