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Self-healing hydrogels incorporating hyaluronic acid, poly(acrylic acid), and ferric ions for flexible sensors, and wound healing

Version 1.0

Gharakhloo, Mosayeb; Khodami, Samaneh; Eskandarinia, Asghar; Karbarz, Marcin, 2025, "Self-healing hydrogels incorporating hyaluronic acid, poly(acrylic acid), and ferric ions for flexible sensors, and wound healing", https://doi.org/10.58132/NCNXGY, Dane Badawcze UW, V1

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Description

This dataset contains data and results from a project focused on the development of multifunctional hydrogels composed of polyacrylic acid (pAAc), hyaluronic acid (HA), and ferric ions (Fe3+) used as non-covalent crosslinkers. The hydrogels were synthesized via a simple one-pot method. The project explores how varying HA content influences the mechanical, adhesive, and functional properties of the resulting materials.

Systematic rheological and mechanical testing revealed that incorporating HA improves tensile strength, toughness, and elasticity while preserving the integrity of the polymer network. Notably, the hydrogels demonstrated strong adhesion to a range of surfaces (e.g., porcine tissue) and exhibited excellent self-healing capabilities.

Among the formulations tested, the hydrogel containing 0.6% HA (pAAc/Fe3+/HA-0.6%) showed the best balance of mechanical strength and self-healing behavior and was selected for further evaluation. Electrical resistance measurements confirmed its potential as a flexible, wearable sensor, with stable and repeatable responses to deformation. Additional assays indicated that the hydrogel supports wound healing and possesses both antibacterial and antioxidant activity.

The data and analyses provided here support the development of robust, biocompatible hydrogels for potential use in wound care, wearable electronics, and other biomedical applications.

Subject
Chemistry
Keyword

hydrogel, self-healing, bilayer wound dressing, flexible sensor, hyaluronic acid, poly(acrylic acid), ferric ions

CC0 Creative Commons Zero 1.0 CC0 Creative Commons Zero 1.0

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1 to 8 of 8 Files
Tensile_tests.tab
Tabular Data - Original format: MS Excel (XLSX) - 98.2 KB - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
8 Variables, 2328 Observations - UNF:6:x9yiSNPcNqS35DuMtO6WIg==
Mechanical performance—Tensile stress–strain curves for hydrogels with varying hyaluronic acid content (0, 0.3, 0.6, and 1 wt%).
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Stress_at_break.tab
Tabular Data - Original format: MS Excel (XLSX) - 36 B - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
2 Variables, 4 Observations - UNF:6:rQK9MpmiQHdhOzZZb/5U3A==
The fracture stress of the hydrogels changes with increasing hyaluronic acid concentration (0, 0.3, 0.6, and 1 wt%), indicating its role in modulating mechanical properties.
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Toughness.tab
Tabular Data - Original format: MS Excel (XLSX) - 46 B - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
2 Variables, 4 Observations - UNF:6:7SqYmSsc4kkh1YlD6L/oKQ==
Toughness of the hydrogels changes with different hyaluronic acid concentrations (0, 0.3, 0.6, and 1 wt%), highlighting its impact on mechanical performance.
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Compression.tab
Tabular Data - Original format: MS Excel (XLSX) - 597.9 KB - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
8 Variables, 10570 Observations - UNF:6:GCW1caUKtyFYBqoBXSpr0g==
This dataset shows the compression stress–strain behavior of hydrogels formulated with different concentrations of hyaluronic acid (0, 0.3, 0.6, and 1 wt%), used to evaluate compressive strength and elasticity.
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Self-healing.tab
Tabular Data - Original format: MS Excel (XLSX) - 66.6 KB - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
8 Variables, 1146 Observations - UNF:6:MA4ZfPLX5ROyB/P2379/0A==
Assessment of self-healing behavior over time for the hydrogel formulation with 0.6% hyaluronic acid, highlighting recovery of mechanical integrity.
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Amplitude.tab
Tabular Data - Original format: MS Excel (XLSX) - 3.2 KB - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
9 Variables, 51 Observations - UNF:6:hdVsptgPimV1VxfGzOfWFg==
Amplitude tests of hydrogels with different hyaluronic acid concentrations (0, 0.3, 0.6, and 1 wt%) to assess their mechanical stability under strain.
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Frequency.tab
Tabular Data - Original format: MS Excel (XLSX) - 995 B - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
9 Variables, 16 Observations - UNF:6:F9Zx5pZQbdSgJLvatnaoXw==
Frequency sweep tests of hydrogels with varying hyaluronic acid content (0%, 0.3%, 0.6%, and 1% by weight) to evaluate their viscoelastic response over a range of frequencies.
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Adhesion_test.tab
Tabular Data - Original format: MS Excel (XLSX) - 6.4 KB - Jun 3, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
6 Variables, 179 Observations - UNF:6:tyV5qDhf+CIWknMKARa3Ag==
Adhesion performance of hydrogels with 0.3%, 0.6%, and 1% hyaluronic acid, tested to assess substrate bonding strength.
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